Optical Waveguide

OWLS label-free biosensors
Introducing the OWLS™ system; a label free‚ real-time biomolecularinteraction analyses device based on the optical grating coupler sensortechnology.


The OWLS system is particularly valuable for the detailed analysis of abinding process‚ with a view to elucidate the underlyingphysico-chemical mechanism. Its high sensitivity‚ coupled with the easewith which experiments can be run under controlled hydrodynamicconditions‚ enables many crucial details to be revealed‚ which remainhidden when investigated using less-advanced methods. Thus‚ forfundamental biological research‚ both at the level of individualmolecules and of clusters operating on the surfaces of cells‚ and forresearch aimed at developing diagnostic biosensors and biomaterials‚OWLS is an extremely valuable tool.

Application areas
Biomolecular interaction studies
Biosensors and immunosensors
Living cells: kinetics of adhesion‚ growth and spreading
Biocompatibility studies
Membrane protein__lipide bilayer interactions
Protein - DNA/RNA interactions‚ nucleic acids‚ genosensors
Bionanotechnology
Drug discovery and development
Molecular self-assembly and nanoscience


OWLS 120 Standard System

The OWLS 120 is a state-of-the-art device for the in situ study of thekinetics and equilibrium constants of surface processes. As alabel-free biosensor‚
it is a very high sensitivity‚ real-time technology for investigating adsorption and binding processes.

The OWLS 120 Standard System includes: main measuring unit withoptomechanical system‚ built-in PC‚ integrated sensor holder and SIS-06sample injection subunit‚ TC-40 temperature control subunit‚ andcomputer peripherials including 17" LCD Monitor‚ keyboard‚ mouse andUSB flash drive.

Product description
Optomechanical system
Electronic signal processing and controlling unit
Built in PC with hard disk‚ CD reader/writer‚ USB ports
Power supplies
Integrated sensor holder
SIS-06 sample injection subunit‚ see separate datasheet
Optional configuration with SIS-03 sample injection subunit - see separate datasheet
TC-40 temperature control subunit‚ see separate datasheet
Optional units
Electro-Chemical OWLS System
OWLS measurements with ITO coated OW 2400 sensor & EC cuvette.Transparent electrically conductive layer on the sensor surface allowsinvestigation of surface adsorption processes under electric field.
Fluoro-OWLS measuring System
OWLS measurements with special fluoro-cuvette allows combinedfluorescent labeled & OWLS measurements. Optional Fluoro__BioSensesoftware module is offered for data evaluation & interpretation.